Royal Air Force Typhoon jets have operated alongside French warplanes in a combined operation on an underground arms cache in Syrian territory employed by the IS group, per a report from the UK's MoD.
The facility, identified by reconnaissance, was believed to be storing arms and explosives, the statement said, and was positioned in mountains just to the north of the ancient city of Palmyra in Syria's central region.
"The RAF jets utilized precision-guided Paveway IV munitions to strike a series of entry passages down to the site... initial indications suggest the objective was successfully hit," the MoD said.
There was no sign of any harm to civilians in the strike conducted Saturday night and every plane involved made a safe return, the MoD added.
The British jets were assisted by a Voyager tanker plane.
Daesh - alternatively referred to as Daesh - imposed militant control over parts of Iraq and Syria prior to its 2019 collapse.
"This strike demonstrates British leadership, and resolve to work closely with allied nations, to stamp out any revival of the terrorist group and their dangerous and violent ideologies in the region," UK Defence Secretary the minister said.
UK warplanes have conducted overwatch operations over Syrian airspace to "prevent any efforts to regroup" of IS following its military defeat at the Baghuz confrontation in the year 2019, the ministry said.
"I want to thank every member of the UK armed forces involved in this strike for their professionalism and their valour," he said. "They were part of a great many British troops deployed over the festive period. This mission, to remove terrorist threats who endanger our way of life, highlights how British military are always on standby, throughout the year, ensuring Britain's security domestically and powerful internationally."
In December, the US military executed what it termed a "massive strike" on Islamic State objectives in the country, after an attack resulted in the deaths of two American soldiers and a local interpreter in Palmyra.
The U.N. reports Islamic State still has between 5,000 and 7,000 militants in both countries.